![]() SPS is the generic form of the brand-name drugs Kalexate and Kionex. Other drugs used for hyperkalemia (high potassium) besides Lokelma include sodium polystyrene sulfonate (SPS). How does Lokelma compare with alternatives such as SPS? * See “ What should be considered before taking Lokelma?” below for details. If you’re taking Lokelma while you’re having hemodialysis and you have diarrhea or vomiting, you should talk with your doctor. Hemodialysis (a treatment that filters waste from your blood) increases your risk of getting sick and having vomiting or diarrhea. Talk with your doctor if you have diarrhea and you’re taking Lokelma. Taking Lokelma and having severe diarrhea can cause your potassium level to become too low. Having severe diarrhea can cause you to lose electrolytes (minerals), such as potassium. If you have problems with your digestive system, such as severe constipation or a blockage in your intestines, Lokelma can make your symptoms worse. ![]() No, diarrhea and constipation aren’t side effects of Lokelma. Does Lokelma cause diarrhea or constipation? * A drug’s active ingredient makes the drug work. This lowers the level of potassium in your digestive tract and blood. ![]() This means that once Lokelma binds to potassium, the potassium and the drug are released through your stool. ![]() Your body doesn’t absorb Lokelma’s active ingredient,* sodium zirconium cyclosilicate, through your intestines. This is Lokelma’s mechanism of action (the way the drug works in your body). Lokelma works by binding (attaching) to potassium in your digestive tract (your stomach and intestines). What are some frequently asked questions about Lokelma?įind answers to some common questions about Lokelma.
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